cenobamate will increase the amount or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Check Carefully. Look at a dose reduction of CYP2C19 substrates, as clinically ideal, when used concomitantly with cenobamate.diazepam improves levels of lomitapide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Wa